Title : Decreasing Grey Matter in Multiple Sclerosis; A serious disorder in the brain
Presenter : Jes Paul
Albany Medical College, USA
Abstract : Multiple sclerosis (MS) is a chronic degenerative disease of the central nervous system that is frequently accompanied by decline in grey matter composition .
Specific patterns of brain atrophy in MS is associated with reduced gray matter . Even earlier studies also showed the abnormalities in gray matter networks several neurological and psychiatric disorders, such as Alzheimer disease and schizophrenia. The link between gray matter lessening and disability is more pronounced as the MS progresses .
The study, aimed to investigate decreasing gray matter content in MS by hypothesing that the more pronounced network disorganization and disability there is more worse decrease in grey matter in MS.A very random topology in MS patients was related to reduced grey matter, explaining variance beyond conventional MRI and volumetric measures. This suggests that during the progression of MS the gray matter networks will diminish contributing to worsened disability,neuropathophysiological and cognitive impairment. Advancements in to the grey matter morphology showcases an improved relationship with clinical and cognitive observed profiles in MS.
In future research grey matter network-based pathology in MS which lead to cognitive and physical disability, should be addressed so that a serious neurological disorder like ms can be tackled to an extent.
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